2025

Doctor thesis

Keita Hirono

"Design of mesenchymal stem cell manufacturing processes considering spatial heterogeneity and dynamic variations"

Master thesis

Kousuke Nemoto

"Model-based design and operation support of cultivation processes in monoclonal antibody manufacturing"

Mari Shinjo

"Modelling and design of freeze-drying processes considering efficiency and quality aspects"

Masahito Saito

"Development of a manufacturability prediction model for tabletop tablet manufacturing based on classification of tableting failures"

Shunsei Yayabe

"Model-based process design for flow synthesis of drug substances using Stevens oxidation"

Bachelor thesis

Atsunori Shimizu

"Multidimensional assessment of cryoprotective agents for stem cells"

Kazuma Ando

"Infrastructure-gap analysis for green hydrogen society in Japan"

Rei Aoyagi

"Modeling and evaluation of drug manufacturing processes considering new modalities"

Yusuke Kawada

"Development of a healthcare society simulator for effective allocation of medical resources"

Yuki Yamashita

"Integrated process design of passage culture and freezing for mesenchymal stem cells towardestablishment of working cell banks"

2024

Doctor thesis

Kozue Okamura

"Model-based design framework for antibody drug production processes considering perspectives from cell characteristics to social requirements"

Master thesis

Yusuke Ichida

(Title in Japanese)

Saho Okazaaki

(Title in Japanese)

Bachelor thesis

Daiki Ikuta

"Cost-effectiveness analysis of new modality drugs considering stratified treatment"

Korbboon Sathirakul

"Modeling and multi-criteria assessment of purification processes for monoclonal antibody production"

Masaharu Fujioka

"Modeling and design of freezing processes for stem cell-derived spheroids"

Rei Tamaki

"Computer-aided design of cryoprotective agents for stem cells"

Sota Wada

"Modeling and design of ultrasound-assisted decontamination processes in pharmaceutical manufacturing"

2023

Doctor thesis

Junu Kim

"Model-based characterization and evaluation of batch and flow syntheses in drug substance manufacturing"

Masahiro Yamada

"Model-based design methodology for injectable manufacturing processes considering product, technology, and market characteristics"

Master thesis

Akinori Shigeyama

"Simulation and design of integrated upstream and downstream monoclonal antibody production processes"

Shungo Matsueda

"Design of reaction and extraction processes in drug substance production with flow synthesis"

Bachelor thesis

Ayumi Goto

"Prediction model of quality and manufacturability based on powder properties for table-top tablet manufacturing"

Mari Shinjo

"Design of freeze-drying processes considering quality aspects using computational fluid dynamics"

Kousuke Nemoto

"Decision-support method for pharmaceutical excipients considering supply stability"

2022

Doctor thesis

Philipp Zuercher

"Data-driven decision support for equipment condition monitoring and predictive maintenance in biopharmaceutical drug product manufacturing"

Yusuke Hayashi

"Multiscale design of cryopreservation processes for human induced pluripotent stem cells"

Master thesis

Keita Hirono

"Method for designing mesenchymal stem cell cultivation processes incorporating system namics and variabilities"

Bachelor thesis

Yusuke Ichida

(Title in Japanese)

Kota Oishi

"Data standardization and parameterization of cultivation processes in monoclonal antibody production"

Saho Okazaki

(Title in Japanese)

Masahito Saito

"Modularized simulation for designing ultrasound-assisted H2O2 decontamination processes"

2021

Doctor thesis

Anicia Zeberli

"Computer-aided approach for design and operation support of changeover processes in biopharmaceutical drug product manufacturing"

Kensaku Matsunami

"Integrated design framework for solid drug product manufacturing processes considering continuous technology"

Master thesis

Kozue Okamura

"Modeling and design of cell cultivation processes in monoclonal antibody production"

Nozomi Takahashi

"Robust design of capture chromatography processes in monoclonal antibody production"

Danny Harjowinoto

"Quality and productivity assessment of small-scale tablet manufacturing"

Bachelor thesis

Akinori Shigeyama

(Title in Japanese)

Shungo Matsueda

(Title in Japanese)

Yuki Yoshiyama

(Title in Japanese)

2020

Doctor thesis

Haruku Shirahata

"Holistic design of biopharmaceutical production processes considering single-use technology and continuous manufacturing"

Keisho Yabuta

"Model-based design of hydrogen peroxide decontamination processes in sterile drug product manufacturing"

Master thesis

Junu Kim

"Decision support method for the choice between batch and flow syntheses in drug substance manufacturing"

Kosuke Kusumoto

(Title in Japanese)

Tomohiro Miura

(Title in Japanese)

Masahiro Yamada

"Design method for injectable manufacturing processes considering continuous and batch modes"

Bachelor thesis

Hiroaki Kuroda

(Title in Japanese)

Tatsuki Yoshida

(Title in Japanese)

2019

Master thesis

Koichi Hayashi

(Title in Japanese)

Yusuke Hayashi

"Design of freezing processes for human induced pluripotent stem cells towards industrial manufacturing"

Masaki Shiokaramatsu

(Title in Japanese)

Bachelor thesis

Kozue Okamura

"Dynamic simulation and process assessment of cell cultivation modes in monoclonal antibody production"

Nozomi Takahashi

(Title in Japanese)

2018

Doctor thesis

Gioele Casola

"Framework for data-driven process improvement and operations support in biopharmaceutical drug product manufacturing"

Master thesis

Shohei Fukuhara

(Title in Japanese)

Norikazu Harada

(Title in Japanese)

Kensaku Matsunami

"Design method of solid drug product manufacturing processes in clinical development"

Philipp Zuercher

"Multi-stage and Multi-objective Decision Support Tool for Process Design of Biopharmaceutical Drug Product Manufacturing" (ETH Zurich)

Bachelor thesis

Kosuke Kusumoto

(Title in Japanese)

Masahiro Yamada

"Lot-sizing method in parenterals manufacturing processes based on economic evaluation" (Original title in Japanese)

2017

Master thesis

Masaaki Ito

"Method for material loss reduction in drug product manufacturing processes" (Original title in Japanese)

Haruku Shirahata

"Design methodology of parenterals manufacturing processes considering the choice between single-use and multi-use technologies"

Keisho Yabuta

"Design methodology of decontamination processes using hydrogen peroxide in pharmaceutical manufacturing"

Shant Dakessian

"Systematic generation and evaluation of equipment technology options in parenterals manufacturing" (ETH Zurich)

Anicia Zeberli

"Application of computational fluid dynamics for equipment redesign in sterile manufacturing of biopharmaceuticals" (ETH Zurich)

Bachelor thesis

Masaki Shiokaramatsu

"Design of working cell bank of allogeneic iPS cells using Monte Carlo simulation" (Original title in Japanese)

2016

Bachelor thesis

Yuuki Uchida

"Method for reducing EHS risks of solvent usage of pharmaceutical drug substance manufacturing" (Original title in Japanese)

Akira Hashimoto

"Method for supporting countermeasures for reducing unused medicines" (Original title in Japanese)

Kensaku Matsunami

"Design method for pharmaceutical tablet manufacturing processes considering the choice between batch and continuous technologies" (Original title in Japanese)

2015

Bachelor thesis

Haruku Shirahata

(Title in Japanese)

Akiko Segawa

(Title in Japanese)

Keisho Yabuta

(Title in Japanese)

2014

Master thesis

Gioele Casola

"Systematic retrofitting methodology for pharmaceutical drug purification processes"

Bachelor thesis

Masaaki Ito

(Title in Japanese)