Gioele Casola

Short C.V.

2015 - 2018	PhD Student, The University of Tokyo, Japan
2013 - 2015	Master of Science in Chemical and Bioengineering, ETH Zurich, Switzerland Thesis on Pharmaceutical Process System Engineering, The University of Tokyo, Japan
2011 - 2013	Bachelor of Science in Chemical and Bioengineering, ETH Zurich, Switzerland

Research

Assessment, optimization and design of sterile manufacturing processes of biopharmaceuticals, with the focus on Clean- Sterilization-Drying-in-place (CIP/SIP/DIP) of filling facilities:
- Knowledge-based and statistical modelling
- Computational Fluid Dynamic simulation
- Optimization

Manufacturing data pre-processing and analytics for batch operated CIP/SIP/DIP processes:
- Ontology development
- Machine Learning
- Information-knowledge translation

Development of CAPE tool for Industry 4.0 and digitalization in biopharmaceutical sterile manufacturing:
- Predictive maintenance
- Information Balance

Publications

Anicia Zeberli, Gioele Casola, Sara Badr, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, 2018, "Approach for Multicriteria Equipment Redesign in Sterile Manufacturing of Biopharmaceuticals", Journal of Pharmaceutical Innovation, accepted

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, 2018, "Data Mining-based Algorithm for Pre-processing Biopharmaceutical Manufacturing Records", Computer Aided Chemical Engineering, 44, 2263–68

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, 2018, "Uncertainty-Conscious Methodology for Process Performance Assessment in Biopharmaceutical Drug Product Manufacturing", AIChE Journal, 64, 1272–84.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, 2017, "Integrated Process Performance Assessment Considering Uncertainty in Biopharmaceutical Manufacturing Operations", Computer Aided Chemical Engineering, 40, 2227–32

Gioele Casola, Lukas Gallus Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, 2016, "Mid-term scheduling model based on state-task-network considering plant specific constraints in pharmaceutical manufacturing", Computer Aided Chemical Engineering, 38, 1141–46

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, 2015, "Systematic Retrofitting Methodology for Recrystallization of Thermally Unstable Active Pharmaceutical Ingredients", Computer Aided Chemical Engineering, 37, 2189–94.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, 2015, "Systematic Retrofitting Methodology for Drug Purification Processes", Computers & Chemical Engineering, 80, 177–88.

Alexander Stepuk, Gioele Casola, Christoph Schumacher, Karl Kraemer, Wendelin Stark, 2014, "Purification of NaYF4-Based Upconversion Phosphors", Chemistry of Materials, 26, 2015–20.

Conferences

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Framework for data-driven process improvement and operations support in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineering Japan (SCEJ) 50th Autumn Meeting, 2018, Kagoshima, Japan.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data mining-based algorithm for pre-processing biopharmaceutical manufacturing records", Oral, PSE-2018 Conference, 2018, San Diego, United State.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Data-driven approaches for process improvement and operation support in biopharmaceutical drug product manufacturing", Oral, Society of Chemical Engineering Japan (SCEJ) 83rd Annual Meeting, 2018, Osaka, Japan.

Gioele Casola "Real-time process failure prediction leveraging big data analytics for biopharmaceutical drug product manufacturing", Poster Session, 2nd ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Innovation, 2018, Zurich, Switzerland

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Integrated process performance assessment considering uncertainty in biopharmaceutical manufacturing operations", Oral, ESCAPE-27 Conference, 2017, Barcelona, Spain.

Gioele Casola "Model 4: Improvement of CIP/SIP processes considering uncertainty", Oral, ISPE Japan Affiliate Annual Meeting 2017 (15th Aniversary Meeting), 2017, Toyama, Japan

Gioele Casola "Monte Carlo simulation-based method for process performance assessment in sterile manufacturing of biopharmaceuticals", Poster Session, ETH Zürich–The University of Tokyo Strategic Partnership Symposium on Science, Design, Manufacturing, and Information, 2017, Tokyo, Japan

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Biopharmaceutical process optimization: needs and benefits of numerical simulation approaches" Poster Session, The 22nd SCEJ Symposium on Fluidization & Particle Processing, 2016, Tokyo, Japan.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Monte carlo simulation-based method for process performance assessment in sterile manufacturing of biopharmaceuticals", Poster Session, 2016 AIChE Annual Meeting, 2016, San Francisco, United State.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Process performance assessment based on stochastic simulation in sterile drug product manufacturing", Oral, Society of Chemical Engineering Japan (SCEJ) 48th Autumn Meeting, 2016, Tokushima, Japan.

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Process Model of Sterile Drug Product Manufacturing for Yield Enhancement", Oral, the 7th International Symposium on Design, Operation & Control of Chemical Processes (PSE Asia 2016), 2016, Tokyo, Japan.

Gioele Casola, Lukas Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama, "Mid-term scheduling model based on state-task netwotk for considering plant specific constraints in pharmaceutical manufacturing ", Poster Session, ESCAPE-26 Conference, 2016, Portorož, Slovenia.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, "Systematic Retrofitting Methodology for Pharmaceutical Drug Purification Processes", Oral, American Institute of Chemical Engineers Annual Meeting (AIChE), 2015, Salt Lake City, United State.

Gioele Casola, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama, "Systematic Retrofitting Methodology for Recrystallization of Thermally Unstable Active Pharmaceutical Ingredients", Poster Session, PSE-2015/ESCAPE-25 Conference, 2015, Copenhagen, Denmark.

Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao, "Retrofitting methodology for pharmaceutical drug purification process using simulation technologies", Poster Session, Society of Chemical Engineering Japan (SCEJ), 2015, Tokyo, Japan.

Others

Gioele Casola "Interview 創薬・創剤人　リアルデータを基にしたアルゴリズムで工程改善　Gioele Casola氏" Pharm Tech Japan, 34, 822–823 (2018)