Sugiyama-Badr Laboratory

Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama "A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells" 33rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 52, 65–70 (2023)

Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior" 33rd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 52, 985–990 (2023)

Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama
"An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2203–2208 (2022)

Masahiro Yamada, Isuru A. Udugama, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama
"Integrated design of injectable manufacturing processes considering characteristics of process- and discrete-manufacturing systems"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2191–2196 (2022)

Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama
"Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2137–2142 (2022)

Philipp Samuel Zuercher, Sara Badr, Stephanie Knueppel, Hirokazu Sugiyama
"Data-driven operation support for equipment deterioration detection in drug product manufacturing"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 1519–1524 (2022)

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, Sara Badr
"Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 877–882 (2022)

Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama
"Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 745–750 (2022)

Kensaku Matsunami, Sara Badr, Hirokazu Sugiyama
"Framework for designing solid drug product manufacturing processes based on economic and quality assessment"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 223–228 (2022)

Hirokazu Sugiyama
"Pharma PSE: a multiscale approach for reimagining pharmaceutical manufacturing"
14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 59–64 (2022)

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama
"Design space determination of mesenchymal stem cell cultivation by dynamic modeling under uncertainty"
32nd European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 51, 721–726 (2022)

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
"Model-based design of freezing temperature profile for human induced pluripotent stem cells"
Cryobiology, 97, 274 (2020)

Samir Diab, Sara Badr, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis
"Dynamic simulation and visualisation of ph-modulated fed-batch fermentation for mab production from CHO cell cultures"
30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1657–1662 (2020)

Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama
"Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production"
30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 1609–1614 (2020)

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama
"Integrated design of process configuration and scheduling for hydrogen peroxide decontamination in biopharmaceutical injectable manufacturing"
30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 853–858 (2020)

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama
"Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition"
30th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 48, 265–270 (2020)

Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama
"Integrated white-box models for designing freezing processes of human induced pluripotent stem cells considering diversity within a container"
29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 877–882 (2019)

Haruku Shirahata, Samir Diab, Hirokazu Sugiyama, Dimitrios I. Gerogiorgis
"Dynamic modelling and simulation of Chinese hamster ovary (CHO) cell fermentation for advanced biopharmaceutical manufacturing"
29th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 46, 673–678 (2019)

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Data mining-based algorithm for pre-processing biopharmaceutical manufacturing records"
Proceedings of 13th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 44, 2263–2268 (2018)

Kensaku Matsunami, Shuichi Tanabe, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama
"Economic evaluation of batch and continuous manufacturing technologies for solid drug products during clinical development"
Proceedings of 13th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 44, 2131–2136 (2018)

Hirokazu Sugiyama, Yusuke Morikawa, Mai Matsuura, Menghe Xu
"Quantitative analysis on the relevance of regulatory constraints in designing pharmaceutical manufacturing processes"
Proceedings of 13th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 44, 2119–2124 (2018)

Haruku Shirahata, Shant Dakessian, Masahiko Hirao, Hirokazu Sugiyama
"Multilayer and multiobjective design platform for drug product manufacturing processes of biopharmaceuticals"
Proceedings of 13th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 44, 301–306 (2018)

Kensaku Matsunami, Takuya Nagato, Koji Hasegawa, Masahiko Hirao, Hirokazu Sugiyama
"Industrial scale experiments towards the development of process evaluation models for continuous pharmaceutical tablet manufacturing"
Proceedings of 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1655–1660 (2018)

Keisho Yabuta, Haruka Futamura, Koji Kawasaki, Masahiko Hirao, Hirokazu Sugiyama
"Models for designing hydrogen peroxide decontamination processes in sterile drug product manufacturing"
Proceedings of 28th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 43, 1613–1618 (2018)

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama
"Risk evaluation models for the design of parenterals manufacturing processes"
Proceedings of 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2791–2796 (2017)

Hirokazu Sugiyama, Kensaku Matsunami, Keisho Yabuta
"Process systems engineering approaches for drug product manufacturing: from tablets to injectables"
Proceedings of 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2785–2790 (2017)

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Integrated process performance assessment considering uncertainty in biopharmaceutical manufacturing operations"
Proceedings of 27th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 40, 2227–2232 (2017)

Kensaku Matsunami, Takuya Miyano, Hiroaki Arai, Hiroshi Nakagawa, Masahiko Hirao, Hirokazu Sugiyama
"Design method for pharmaceutical tablet production considering batch & continuous technologies"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), C223 (2016)

Keisho Yabuta, Masahiko Hirao, Hirokazu Sugiyama
"Process model of sterile drug product manufacturing for yield enhancement"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D132 (2016) Excellent Student-Paper Award

Haruku Shirahata, Masahiko Hirao, Hirokazu Sugiyama
"Selection support method of single-use vs. multi-use technologies in sterile drug product manufacturing"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D123 (2016) Excellent Student-Paper Award

Masaaki Ito, Yasuyuki Yoshioka, Hayao Nakanishi, Masahiko Hirao, Hirokazu Sugiyama
"Product loss reduction in batch manufacturing of sterile drug products"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D122 (2016)

Lukas Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
" Data-driven approach for increasing yield in drug product manufacturing "
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D121 (2016)

Gioele Casola, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Creating hybrid-model-based simulation environment for sterile drug product manufacturing"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D113 (2016)

Hirokazu Sugiyama
"Conducting process systems engineering research on pharmaceutical manufacturing"
Proceedings of the 7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2016), D111 (2016)

Gioele Casola, Lukas Gallus Eberle, Christian Siegmund, Markus Mattern, Hirokazu Sugiyama
"Mid-term scheduling model based on state-task-network considering plant specific constraints in pharmaceutical manufacturing"
Proceedings of 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 1141–1146 (2016)

Hirokazu Sugiyama, Akiko Segawa, Satoshi Yoshikawa, Takayuki Toyama, Hayao Nakanishi, Emi Kikuchi-Uehara, Masahiko Hirao
"Multiobjective retrofitting methodology for manufacturing processes of active pharmaceutical ingredients considering environmental, health and safety risks"
Proceedings of 26th European Symposium on Computer Aided Process Engineering, Elsevier, Computer Aided Chemical Engineering, 38, 79–84 (2016)

Hirokazu Sugiyama, Masaaki Ito, Masahiko Hirao
"Process-based method for reducing product losses in pharmaceutical manufacturing"
12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 36, 2189–2194 (2015)

Gioele Casola, Hirokazu Sugiyama, Satoshi Yoshikawa, Hayao Nakanishi, Masahiko Hirao
"Systematic retrofitting methodology for recrystallization of thermally unstable active pharmaceutical ingredients"
12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 36, 2171–2176 (2015)

Lukas Gallus Eberle, Elisabet Capón-Garcia, Martin Senninger, Hirokazu Sugiyama, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
"Optimal scheduling of liquid drug product manufacturing"
12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 36, 2033–2038 (2015)

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
"Improving pharmaceutical batch production processes with data-based tiered approach"
12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 36, 1967–1972 (2015)

Lukas Gallus Eberle, Hirokazu Sugiyama, Stavros Papadokonstantakis, Andreas Graser, Rainer Schmidt, Konrad Hungerbühler
"Data-based approach for efficient yield enhancement in pharma production"
Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 33, 463–468 (2014)

Hirokazu Sugiyama, Masahiko Hirao
"Integration framework for improving quality and cost-effectiveness in pharmaceutical production processes"
Proceedings of the 24th European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 33, 379–384 (2014)

Hirokazu Sugiyama, Sandra Schinzel, Georg Müller, Rainer Schmidt
“Applying process systems engineering for continuous improvement in pharmaceutical production”
Proceedings of the 6th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia 2013), 600–605 (2013)

Hirokazu Sugiyama, Rainer Schmidt
“Business model of continuous improvement in pharmaceutical production processes”
Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 32, 697–702 (2013)

Lukas Gallus Eberle, Hirokazu Sugiyama, Rainer Schmidt
“Improving lead time of sterile drug product manufacturing using Monte Carlo simulation”
Proceedings of the 23rd European Symposium on Computer Aided Process Engineering, Computer Aided Chemical Engineering, 32, 685–690 (2013)