Yusuke Hayashi

Assistant professor

Short C.V.

2022 –

Assistant professor of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo
2019 – 2022

PhD in Chemical System Engineering, The University of Tokyo
2017 – 2019

Master of Engineering in Chemical System Engineering, The University of Tokyo
2013 – 2017

Bachelor of Engineering in Chemical Engineering, Kyoto University

Mail

y-hayashi@pse.t.u-tokyo.ac.jp

TEL

26876 (Add the last 4 digits to +81-3-5841.)

Research
Publications
Conference proceedings (peer reviewed)
Conferences
Conferences (as a co-author)
Technical papers and reports
Books and book chapters
Awards

Research

I’m focusing on pharmaceutical manufacturing processes and supply chains from a "multiscale" perspective that covers everything from molecular scales to social scales.

Publications

Conference proceedings (peer reviewed)

Conferences

Yusuke Hayashi, Masaharu Fujioka, Yuta Yamaguchi, Tetsuya Fujii, Hirokazu Sugiyama, "A hybrid model for determining design spaces in freezing processes of human induced pluripotent stem cell-derived spheroids", Oral, ESCAPE35, 6-9 July 2025, KU Leuven Campus Ghent, Ghent, Belgium
Yusuke Hayashi, Atsunori Shimizu, Rei Tamaki, Hirokazu Sugiyama, "Multidimensional assessment of cryoprotective agents for stem cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
Yusuke Hayashi, Rei Tamaki, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "Computer-aided exploration of cryoprotective agents for stem cell manufacturing", Poster, 2024 AIChE Annual Meeting, 27-31 october 2024, San Diego Convention Center, Hilton San Diego Bayfront, U.S.A.
Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "Computer-aided optimization of cooling temperature profiles in slow freezing for human induced pluripotent stem cells", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "Optimization of temperature profiles in freezing processes for human iPS cells using simulation", Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama, "A Multilayered approach to continuous freezing process design for human induced pluripotent stem cells", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
Yusuke Hayashi, Akinori Shigeyama, Hirokazu Sugiyama, "Screening support method of cryoprotective agents for stem cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
Yusuke Hayashi, Benedikt X. Scholz, Hirokazu Sugiyama, "A CFD-model-based approach to continuous freezing process design for human induced pluripotent stem cells", Poster, 33rd European Symposium on Computer-Aided Process Engineering (ESCAPE-33), 18-21 June 2023, Royal Olympic Hotel, Athens, Greece
Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama, "Continuous freezing process design for human induced pluripotent stem cells using CFD simulation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Yusuke Hayashi, Hirokazu Sugiyama, "A hybrid-model-based approach to continuous freezing process design for human induced pluripotent stem cells", Oral, 10th Asian Symposium on Process Systems Engineering (PSE Asia 2022), 11-14 December 2022, Indian Institute of Technology Maderas Campus, Chennai, India
Yusuke Hayashi, Hirokazu Sugiyama, "Application of continuous freezing processes for human induced pluripotent stem cells", Oral, The 65th Joint Conference on Automatic Control Engineering, 12-13 November 2022, Utsunomiya University, Tochigi
Yusuke Hayashi, Hirokazu Sugiyama, "Application of tunnel freezers in freezing processes for human induced pluripotent stem cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama, "An agent-based model for cost-effectiveness analysis in the manufacture of allogeneic human induced pluripotent cells in Japan", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19-23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting
Yusuke Hayashi, Hirokazu Sugiyama, "Multiscale design of cryopreservation processes for human induced pluripotent stem cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama, "Fill-freeze-thaw process design of human induced pluripotent stem cells using hybrid models", Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, 22-24 September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting
Yusuke Hayashi, Kota Oishi, Hirokazu Sugiyama, "Cost-effectiveness analysis of allogeneic induced pluripotent cell therapy using agent-based models", Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting
Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama, "Computational fluid dynamics simulation-based scale-up of slow freezing processes for human induced pluripotent stem cells", Oral, The 20th Congress of the Japanese Society for Regenerative Medicine (JSRM), 11-13 March 2021, Virtual meeting
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama, "Model-based assessment of freezing temperature profiles for human induced pluripotent stem cells", Poster, 2020 AIChE Annual Meeting, 16-20 November 2020, Virtual meeting
Yusuke Hayashi, Yuka Nakajima, Hirokazu Sugiyama, "Quantum chemistry and molecular dynamics simulations on cryoprotective agents for human stem cells", Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4-6 November 2020, Virtual meeting
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Life cycle design of packaging based on environmental and functional Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Online
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-Oka, Hirokazu Sugiyama, "Multiobjective dynamic optimization of slow freezing processes for human induced pluripotent stem cells by modeling intracontainer condition", Oral, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August-2 September 2020, Virtual meeting
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Model-based design of freezing temperature profile for human induced pluripotent stem cells", Oral, The 57th Annual Meeting of the Society for Cryobiology (CRYO2020), 21-23 July 2020, Virtual meeting
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Dynamic optimization of the Human iPS Cell slow-freezing process using a mathematical model", The 19th Congress of the Japanese Society for Regenerative Medicine (JSRM) (Abstract only)
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Simulation-based optimization of temperature profiles in slow freezing of hiPS cells", Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting (Abstract only)
Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama, "Scale-up of slow freezing processes for hiPS cells using CFD simulation", Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting (Abstract only)
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Slow freezing process design for human induced pluripotent stem cells by modeling intracontainer variation", Oral, 2019 AIChE Annual Meeting, 10-15 November 2019, Hyatt Regency, Orlando, U.S.A.
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Simulation-based design of slow freezing processes for human induced pluripotent stem cells considering intracontainer variation", Oral, 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 23-27 September 2019, Sapporo Convention Center, Sapporo, Japan
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama, "Freeze-thaw process design of induced pluripotent stem cells using white-box models", Poster, The 29th European Symposium on Computer-Aided Process Engineering (ESCAPE-29), 16-19 June 2019, Evoluon, Eindhoven, Netherland
Yusuke Hayashi, "Process design of iPS cell freezing", Oral, ISPE Japan Affiliate Annual Meeting 2019, 30-31 May 2019, Tower Hall Funabori, Tokyo
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama, "Design of freeze-thaw processes for induced pluripotent stem cells using physical models", Poster, The 18th congress of the Japanese society for regenerative medicine, 21–23 March 2019, Kobe International Conference Center, Hyogo
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama, "Design of freezing processes for human induced pluripotent stemm cells towards industiral manufacturing", Poster, Society of Chemical Engineers, Japan (SCEJ) 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo
Yusuke Hayashi, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama, "Computer-aided design of freeze-thaw processes of induced pluripotent stem cells", Oral, The 8th International Symposium on Design, Operation, and Control of Chemical Processes (PSE Asia 2019), 13-16 January 2019, Chulalongkorn University, Bangkok, Thailand
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Masahiko Hirao, Hirokazu Sugiyama, "Freeze-thaw process design of induced pluripotent stem cells using mechanistic models", Oral, Society of Chemical Engineers, Japan (SCEJ) 50th Autumn Meeting, 18-20 September 2018, Kagoshima University, Kagoshima
Yusuke Hayashi, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama, "Models for designing freeze-thaw process of human induced pluripotent stem cells towards commercial manufacturing", Poster, The 5th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2018), 4-7 September 2018, Kyoto International Conference Center, Kyoto, Japan
Yusuke Hayashi, Masahiro Kino-oka, Ikki Horiguchi, Masahiko Hirao, Hirokazu Sugiyama, "Freeze-thaw process design for industrial manufacturing of induced pluripotent stem cells", Poster, Society of Chemical Engineers, Japan (SCEJ) 83rd Annual Meeting, 13-15 March 2018, Kansai University, Osaka

Conferences (as a co-author)

Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Keisuke Shibukawa, Kazuya Okamoto, Hayao Nakanishi, Hirokazu Sugiyama, "Design space prediction and validation for flow synthesis of drug substances", Oral, Society of Chemical Engineers, Japan (SCEJ) 56th Autumn Meeting, 16-18 September 2025, Shibaura Institute of Technology, Tokyo
Yuki Yoshiyama, Akinori Shigeyama, Sara Badr, Yusuke Hayashi, Kiho Endo, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Model-based analysis of antibody manufacturing processes considering cell clone variability", Oral, Society of Chemical Engineers, Japan (SCEJ) 56th Autumn Meeting, 16-18 September 2025, Shibaura Institute of Technology, Tokyo
Sota Wada, Ryu Okada, Ryo Sakakibara, Yusuke Hayashi, Hirokazu Sugiyama, Junu Kim, "Model-based prediction of 3D culture behavior of mesenchymal stem cells using 2D culture data", Oral, Society of Chemical Engineers, Japan (SCEJ) 56th Autumn Meeting, 16-18 September 2025, Shibaura Institute of Technology, Tokyo
Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Kazuya Okamoto, Keisuke Shibukawa, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic modeling of drug substance synthesis considering slug flow characteristics in a liquid-liquid reaction", Poster, ESCAPE35, 6-9 July 2025, KU Leuven Campus Ghent, Ghent, Belgium
Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "A hybrid-modeling approach to monoclonal antibody production process design using automated bioreactor equipment", Oral, ESCAPE35, 6-9 July 2025, KU Leuven Campus Ghent, Ghent, Belgium
Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Model-based design and operation support of cultivation processes in monoclonal antibody production", Poster, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
Yuki Yamashita, Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "Integrated process design of passage culture and freezing for mesenchymal stem cells toward establishment of working cell banks", Poster, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Keisuke Shibukawa, Kazuya Okamoto, Hayao Nakanishi, Hirokazu Sugiyama, "Model-based process design for flow synthesis of drug substances using Stevens oxidation", Poster, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
Keita Hirono, Yusuke Hayashi, Hirokazu Sugiyama, "Design of mesenchymal stem cell manufacturing processes considering spatial heterogeneity and dynamic variations", Oral, Society of Chemical Engineers, Japan (SCEJ) 90th Annual Meeting, 12-14 March 2025, The University of Science, Tokyo
Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Keisuke Shibukawa, Kazuya Okamoto, Hayao Nakanishi, Hirokazu Sugiyama, "Modeling and application to design for drug substances flow synthesis considering flow characteristics", Oral, The 67th Joint Conference on Automatic Control Engineering, 23-24 November 2024, The Himeji Chamber of Commerce and Industry, Hyogo
Hirokazu Sugiyama, Keita Hirono, Benedikt Scholz1, Isuru A. Udugama, Yusuke Hayashi, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, "Uncertainty-conscious model-based design of human mesenchymal stem cell manufacturing processes", Poster, 2024 AIChE Annual Meeting, 27-31 october 2024, San Diego Convention Center, Hilton San Diego Bayfront, U.S.A.
Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Modeling of monoclonal antibody production processes using data from automated cultivation experiments", Oral, Society of Chemical Engineers, Japan (SCEJ) 55th Autumn Meeting, 11-13 September 2024, Hokkaido University, Hokkaido
Daiki Ikuta, Yusuke Hayashi, Hirokazu Sugiyama, "Modeling of stratified treatment for cost-effectiveness analysis of new drugs and evaluation case studies", Oral, Society of Chemical Engineers, Japan (SCEJ) 55th Autumn Meeting, 11-13 September 2024, Hokkaido University, Hokkaido
Masaharu Fujioka, Yusuke Hayashi, Yudai Yamaguchi, Tetsuya Fujii, Hirokazu Sugiyama, "Design space determination in freezing processes of human inuduced pluripotent stem cell-derived spheroids using hybrid models", Oral, Society of Chemical Engineers, Japan (SCEJ) 55th Autumn Meeting, 11-13 September 2024, Hokkaido University, Hokkaido
Kosuke Nemoto, Sara Badr, Yusuke Hayashi, Yuki Yoshiyama, Kozue Okamura, Mizuki Morisasa, Junshin Iwabuchi, Hirokazu Sugiyama, "Hybrid modeling of CHO-MK cell cultivation for monoclonal antibody production using automated bioreactor equipment", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia
Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Keisuke Shibukawa, Kazuya Okamoto, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic modeling of drug substance flow synthesis using Stevens oxidation considering phase transfer catalyst and slug flow", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia
Rei Tamaki, Yusuke Hayashi, Yuki Uno, Masahiro Kino-Oka, Hirokazu Sugiyama, "An exploration cycle of cryoprotective agents for stem cell manufacturing using computer-aided molecular design approaches", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia
Masaharu Fujioka, Yusuke Hayashi, Hirokazu Sugiyama, "A model-based approach to determining feasible parameter ranges of freezing processes for stem cell-derived spheroids", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid model-based design space determination for an active pharmaceutical ingredient flow synthesis using Grignard reaction", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
Keita Hirono, Yusuke Hayashi, Isuru A. Udugama, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, Hirokazu Sugiyama, "Use of image data in kinetic model development for the design of mesenchymal stem cell cultivation processes", Oral, ESCAPE34-PSE24, 2-6 June 2024, Palazzo dei Congressi -Villa Vittoria, Florence, Italy
Hirono Keita, Yusuke Hayashi, Isuru A. Udugama, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, Hirokazu Sugiyama, "A hybrid model for mesenchymal stem cell cultivation incorporating seeding heterogeneity", Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
Rei Tamaki, Yusuke Hayashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "A circular exploration of cryoprotective agents for stem cells using computer-aided molecular design approaches", Poster, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
Sota Wada, Mohamed Rami Gaddem, Yusuke Hayashi, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama, "Modeling and design of ultrasound-assisted decontamination processes in pharmaceutical manufacturing", Poster, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Model-based approach to design space determination in drug substance flow synthesis using Grignard reaction", Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka
Kosuke Nemoto, Yusuke Hayashi, Hirokazu Sugiyama, "Indicator-based supply stability analysis of pharmaceutical excipients: Method and application", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
Mohamed Rami Gaddem, Yusuke Hayashi, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama, "Model-based design of the next-generation decontamination technology for sterile manufacturing", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Oakamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Model-based design space assessment for flow synthesis of amination reaction via nucleophilic aromatic substitution", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
Keita Hirono, Yusuke Hayashi, Isuru A. Udugama, Mohamed Rami Gaddem, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, Hirokazu Sugiyama, "Hybrid modeling with phase contrast microscopy images for the design of mesenchymal stem cell cultivation processes", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid modeling of a continuous flow Grignard reaction in drug substance synthesis", Oral, The 66th Joint Conference on Automatic Control Engineering, 7-8 October 2023, Tohoku University, Miyagi
Akinori Shigeyama, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama, "Design of integrated upstream and downstream monoclonal antibody production processes using surrogate models", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic study and design space exploration of amination reaction in flow synthesis of drug substances", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
Mohamed Rami Gaddem, Yusuke Hayashi, Benedikt Scholz, Haruka Futamura, Koji Kawasaki, 杉山弘和, "Numerical investigation of aerosol deposition under the effect of airborne acoustic streaming for pharmaceutical process decontamination", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
Benedikt Scholz, Yusuke Hayashi, Mohamed Rami Gaddem, Yuka Higashi, Yuki Uno, Masahiro Kino-oka, Hirokazu Sugiyama, "CFD-based modeling of a continuous forced convection-based freezer unit for human induced pluripotent stem cells considering supercooling", Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Hukuoka
Akinori Shigeyama, Sara Badr, Yusuke Hayashi, Hirokazu Sugiyama, "Simulation and design of integrated upstream and downstream monoclonal antibody production processes", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Kosuke Nemoto, Yusuke Hayashi, Hirokazu Sugiyama, "Decision-support method for pharmaceutical excipients considering supply stability", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Ayumi Goto, Elena Reus, Yusuke Hayashi, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama, "Prediction model of quality and manufacturability based on powder properties for table-top tablet manufacturing", Poster, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Hybrid modelling of active pharmaceutical ingredient flow synthesis in ring-opening reaction of an epoxide with a Grignard reagent", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Masahiro Yamada, Yusuke Hayashi, Sara Badr, Kenichi Zenitani, Kokichi Kubota, Hayao Nakanishi, Hirokazu Sugiyama, "A comprehensive design approach for injectable manufacturing processes considering new technologies and operational aspects", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Benedikt Scholz, Yusuke Hayashi, Isuru Udugama, Masahiro Kino-oka, Hirokazu Sugiyama, "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Mohamed Rami Gaddem, Yusuke Hayashi, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama, "CFD-based investigation of a novel decontamination process using ultrasound technology", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15-17 March 2023, University of Agriculture and Technology, Tokyo
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama, "Kinetic modelling of nucleophilic aromatic substitution reaction in drug substance synthesis", Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano
Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama, "Design space determination of mesenchymal stem cell cultivation by dynamic modeling under uncertainty", Poster, The 32nd European Symposium on Computer-Aided Process Engineering (ESCAPE 32), 12-15 June 2022, Centre de Congrès Pierre Baudis, Toulouse, France
Isuru A. Udugama, Keita Hirono, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama, "Model-based design space determination of mesenchymal stem cell cultivation considering system dynamics and variations", Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting
Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama, "A dynamic and probabilistic design space determination method for mesenchymal stem cell cultivation processes", Poster, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Technical papers and reports

Keita Hirono, Isuru A. Udugama, Yusuke Hayashi, Hirokazu Sugiyama"【Pharma PSE Spotlight】A dynamic and probabilistic design space determination method for mesenchymal stem cells" Pharm Tech Japan, 39, 39–44 (2023)
Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Hybrid-model-based design of fill-freeze-thaw processes for human induced pluripotent stem cells considering productivity and quality" Pharm Tech Japan, 38, 585–588 (2022)
Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells" Pharm Tech Japan, 37, 255–259 (2021)
Yusuke Hayashi, Hirokazu Sugiyama "【Pharma PSE Spotlight】Slow Freezing Process Design for Human Induced Pluripotent Stem Cells by Modeling Intracontainer Variation" Pharm Tech Japan, 35, 2965–2968 (2019)
Masahiro Yamada, Yusuke Hayashi, Keisho Yabuta, Hirokazu Sugiyama "Conference report -50th Autumn Meeting, Society of Chemical Engineers, Japan" Pharm Tech Japan, 34, 3209–3210 (2018)

Books and book chapters

林勇佑 "プロセスモデリングによるヒトiPS細胞の凍結プロセス設計" プロセスインフォマティクスにおけるデータ解析・モデリングと応用展開, 技術情報協会, ISBN 978-4-86798-089-7, 第5章第8節 (2025)

Awards

Dean of the School of Engineering Award, The University of Tokyo, March 2022
Research Encouragement Prize, the Division of SIS at SCEJ 52nd Autumun Meeting, October 2021
Best presentation award, Graduate School of Engineering, Department of Chemical System Engineering, The University of Tokyo, March 2019