Sugiyama-Badr Laboratory

Decision making framework of batch and flow syntheses for drug substance manufacturing

Mohamed Rami Gaddem, Junu Kim, Kensaku Matsunami, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama
“Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation”
Current Opinion in Chemical Engineering , 44 (2024)
DOI: https://doi.org/10.1016/j.coche.2024.101019

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
"Kinetic study and model-based design space determination for a drug substance flow synthesis using amination reaction via nucleophilic aromatic substitution"
Organic Process Research & Development, 28, 5, 1793–1805 (2024)
DOI: 10.1021/acs.oprd.3c00380

Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
"Scenario analysis of vaccine supply for COVID-19 in Japan using mathematical models of infectious diseases"
Journal of Chemical Engineering of Japan, 57 (2024)
DOI: https://doi.org/10.1080/00219592.2024.2313318

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, and Hirokazu Sugiyama "Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent"
Industrial & Engineering Chemistry Research, 62, 43, 17824–17834 (2023)
DOI: https://doi.org/10.1021/acs.iecr.3c02137

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Mechanistic insights into the amination via nucleophilic aromatic substitution"
Reaction Chemistry & Engineering, 8, 2060–2070 (2023) DOI: 10.1039/D3RE00215B

Junu Kim, Yusuke Hayashi, Sara Badr, Hayao Nakanishi, Hirokazu Sugiyama "Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis"
Chemical Engineering Research and Design, 189, 156–166 (2023) DOI: 10.1016/j.cherd.2022.11.012

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 877–882 (2022)

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama, "Model-based comparison of batch and flow syntheses of an active pharmaceutical ingredient using heterogeneous hydrogenation" Computers & Chemical Engineering, 156, 107541 (2022)
DOI: 10.1016/j.compchemeng.2021.107541

Junu Kim, Kensaku Matsunami, Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Determination of critical decision points for COVID-19 measures in Japan" Scientific Reports, 11, 16416 (2021)
DOI: 10.1038/s41598-021-95617-z

Shunsei Yayabe, Junu Kim, Yusuke Hayashi, Keisuke Shibukawa, Kazuya Okamoto, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic modeling of drug substance flow synthesis using Stevens oxidation considering phase transfer catalyst and slug flow", Oral, PSE ASIA 2024, 5-8 August 2024, DoubleTree Resort by Hilton, Penang, Malaysia

Kim Junu, Yusuke Hayashi, Badr Sara, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Model-based approach to design space determination in drug substance flow synthesis using Grignard reaction" Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka

Kim Junu, Sakata Itsushi, Yamatsuta Eitaro, Sugiyama Hirokazu "Data-driven approach to automated reaction process analysis" Oral, Society of Chemical Engineers, Japan (SCEJ) 89th Annual Meeting, 18-20 March 2024, Osaka Metropolitan University, Osaka.

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Oakamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Model-Based Design Space Assessment for Flow Synthesis of Amination Reaction Via Nucleophilic Aromatic Substitution", Poster, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Hybrid modeling of a continuous flow Grignard reaction in drug substance synthesis" Oral, The Society of Instrument and Control Engineers (SICE) 66th Meeting, 7-8 October 2023, Tohoku University, Miyagi

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic study and design space exploration of amination reaction in flow synthesis of drug substances" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Hybrid modelling of active pharmaceutical ingredient flow synthesis in ring-opening reaction of an epoxide with a Grignard reagent", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Junu Kim, Hirokazu Sugiyama "Model-based characterization and evaluation of batch and flow syntheses in drug substance manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Kinetic modelling of nucleophilic aromatic substitution reaction in drug substance synthesis" Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama "Rigorous modeling for assessing batch and flow syntheses of drug substance in heterogeneous hydrogenation", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

Yusuke Ichida, Kensaku Matsunami, Junu Kim, Kozue Okamura, Sara Badr, Hirokazu Sugiyama "Scenario analysis of vaccine supply for COVID-19 using mathematical models of infectious diseases" Poster, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Sara Badr, Hirokazu Sugiyama "Model-based comparison of batch and flow syntheses for heterogeneous hydrogenation reaction in drug substance manufacturing" Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Kensaku Matsunami, Junu Kim, Kozue Okamura, Yusuke Ichida, Shungo Matsueda, Sara Badr, Hirokazu Sugiyama "Mathematical models for infectious diseases considering the impacts of mobility, therapeutic agents, and vaccines" Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Batch and flow syntheses of drug substances: a model-based comparison in heterogeneous hydrogenation" Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4–6 November 2020, Virtual meeting

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Decision support method for the choice between batch and flow syntheses in drug substance manufacturing", Oral, Society of Chemical Engineers, Japan (SCEJ) 51st Autumn Meeting, 24–26 September 2020, Virtual meeting

Junu Kim, Hironori Yonekura, Takeaki Watanabe, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama "Decision support method for the choice between batch and flow syntheses in drug substance manufacturing", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Junu Kim "[学生会員の声]環境破壊は駄目だと誰が決めたのか" 化学工学, 84(6), 40 (2020)