杉山・Badr研究室

Computer-aided Process Design of Mesenchymal Stem Cell Manufacturing

Benedikt X. Scholz, Yusuke Hayashi, Yuka Higashi, Yuki Uno, Mohamed Rami Gaddem, Masahiro Kino-oka, Hirokazu Sugiyama
"Computational Fluid Dynamics Model-based Design of Continuous Forced Convection Freezing Processes for Human Induced Pluripotent Stem Cells Considering Supercooling of Extracellular Solutions"
Chemical Engineering Research and Design, Accepted
DOI: 10.1016/j.cherd.2024.07.037

Mohamed Rami Gaddem, Yusuke Hayashi, Benedikt Scholz, Haruka Futamura, Koji Kawasaki, Hirokazu Sugiyama
“Model-based investigation of a novel decontamination technology: Ultrasound assisted aerosolized hydrogen peroxide”
Chemical Engineering Research and Design , 205, 517–528 (2024)
DOI: 10.1016/j.cherd.2024.04.013

Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation" Computers & Chemical Engineering, 108157 (2023) DOI: 10.1016/j.compchemeng.2023.108157

Isuru A. Udugama, Sara Badr, Keita Hirono, Benedikt X. Scholz, Yusuke Hayashi, Masahiro Kino-oka, Hirokazu Sugiyama "The Role of Process Systems Engineering in Applying Quality by Design (QbD) in Mesenchymal Stem Cell Production" Computers & Chemical Engineering, 108144 (2023) DOI: 10.1016/j.compchemeng.2023.108144

Benedikt X. Scholz, Yusuke Hayashi, Isuru A. Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A multilayered approach to scale-up forced convection-based freezing of human induced pluripotent stem cells" Computers & Chemical Engineering, 163, 107851 (2022), DOI: 10.1016/j.compchemeng.2022.107851

Scholz Benedikt Xaver, Hayashi Yusuke, Gaddem Mohamed Rami, Higashi Yuka, Uno Yuki, Kino-oka Masahiro, Sugiyama Hirokazu "CFD-based modeling of a continuous forced convection-based freezer unit for human induced pluripotent stem cells considering supercooling" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka SIS部会 技術賞

Gaddem Mohamed Rami, Hayashi Yusuke, Scholz Benedikt Xaver, Futamura Haruka, Kawasaki Koji, Sugiyama Hirokazu "Numerical investigation of aerosol deposition under the effect of airborne acoustic streaming for pharmaceutical process decontamination" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Benedikt Scholz, Yusuke Hayashi, Isuru Udugama, Masahiro Kino-oka, Hirokazu Sugiyama "A CFD model-based design of seeding processes for two-dimensional mesenchymal stem cell cultivation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Yusuke Hayashi, Benedikt Scholz, Hirokazu Sugiyama "Continuous freezing process design for human induced pluripotent stem cells using CFD simulation", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Hayashi Yusuke, Scholz Benedikt, Sugiyama Hirokazu "Computational fluid dynamics simulation-based scale-up of slow freezing processes for human induced pluripotent stem cells" Oral, The 20th Congress of the Japanese Society for Regenerative Medicine (JSRM), 11–13 March 2021, Virtual meeting

Hayashi Yusuke, Scholz Benedikt, Sugiyama Hirokazu "Scale-up of slow freezing processes for hiPS cells using CFD simulation" Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting