Sugiyama-Badr Laboratory

Aiming at developing a tool to support process design efforts for the production of monoclonal antibodies (mAb)s. The tool incorporates:
・ Modeling cell cultivation using hybrid models
・ Evaluating the cultivation process in terms of productivity and product quality
・ Developing a framework towards the selection of preferable cultivation modes

Junu Kim, Kensaku Matsunami, Yusuke Ichida, Kozue Okamura, Sara Badr, Hirokazu Sugiyama
"Scenario analysis of vaccine supply for COVID-19 in Japan using mathematical models of infectious diseases"
Journal of Chemical Engineering of Japan, 57 (2024)
DOI: https://doi.org/10.1080/00219592.2024.2313318

Kozue Okamura, Hiroki Tsuchiya, Risa Hamada, Yusuke Hayashi, Sara Badr, Seiichi Ohta, Hirokazu Sugiyama
"A systems evaluation model for the development of companion diagnostics and associated molecularly targeted therapies"
Journal of Pharmaceutical Innovation, 199, 507–514 (2023)
DOI: https://doi.org/10.1007/s12247-023-09788-5

Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama, "Hybrid Modeling of CHO Cell Cultivation in Monoclonal Antibody Production with an Impurity Generation Module" Industrial & Engineering Chemistry Research, 61, 14898–14909 (2022) DOI: 10.1021/acs.iecr.2c00736

Eri Amasawa, Hiroaki Kuroda, Kozue Okamura, Sara Badr, and Hirokazu Sugiyama, "Cost–Benefit Analysis of Monoclonal Antibody Cultivation Scenarios in Terms of Life Cycle Environmental Impact and Operating Cost" ACS Sustainable Chemistry & Engineering, 9, 14012–14021 (2021) DOI: 10.1021/acssuschemeng.1c01435

Junu Kim, Kensaku Matsunami, Kozue Okamura, Sara Badr, Hirokazu Sugiyama, "Determination of critical decision points for COVID-19 measures in Japan" Scientific Reports, 11, 16416 (2021) DOI: 10.1038/s41598-021-95617-z

Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama, "Integrated Design of Biopharmaceutical Manufacturing Processes: Operation Modes and Process Configurations for Monoclonal Antibody Production" Computers & Chemical Engineering, 153, 107422 (2021)
DOI: 10.1016/j.compchemeng.2021.107422

Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama "Modeling and Dynamic Simulation of Cultivation in Monoclonal Antibody Production Considering Cell Metabolic Shifts", Oral, 2023 AIChE Annual Meeting, 5-10 November 2023, Hyatt Regency, Orlando, U.S.A.

Kozue Okamura, Sara Badr, Yusuke Ichida, Akira Yamada, Hirokazu Sugiyama "Development of mechanistic cell cultivation models in monoclonal antibody production using data-driven insights" Oral, Society of Chemical Engineers, Japan (SCEJ) 54th Autumn Meeting, 11-13 September 2023, Fukuoka University, Fukuoka

Kozue Okamura, Sara Badr, Akira Yamada, Hirokazu Sugiyama "Modeling cell metabolic shifts in cultivation processes for monoclonal antibody production", Oral, Society of Chemical Engineers, Japan (SCEJ) 88th Annual Meeting, 15–17 March 2023, University of Agriculture and Technology, Tokyo

Kozue Okamura, Seiichi Ohta, Hirokazu Sugiyama "Modeling approach for cost-effectiveness analysis of companion diagnostics" Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

Kozue Okamura*, Rio Hamada, Hiroki Tsuchiya, Seiichi Ohta, Hirokzau Sugiyama "Cost-effectiveness modelling and analysis of companion diagnostics" Oral, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Kozue Okamura*, Sara Badr, Hirokazu Sugiyama "Hybrid modeling of cell cultivation towards integrated design of monoclonal antibody production processes" Poster, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting Student Award (Poster)

Kozue Okamura*, Sara Badr, Hirokazu Sugiyama "Simulation of cultivation processes in monoclonal antibody production towards the selection of operation modes" Oral, The 9th Asian Symposium on Process Systems Engineering (9th PSE Asia), 4–6 November 2020, Virtual meeting

Kozue Okamura*, Sara Badr, Hirokazu Sugiyama "Process simulation for the decision making on cell cultivation modes in monoclonal antibody production", Abstract, Society of Chemical Engineers, Japan (SCEJ) 85th Annual Meeting

Kozue Okamura*, Sara Badr, Hirokazu Sugiyama "Dynamic simulation and process assessment of cultivation modes in monoclonal antibody production using pilot-scale experimental data", Oral, 2019 AIChE Annual Meeting, 10–15 November 2019, Hyatt Regency, Orlando, U.S.A.

Kozue Okamura* "Continuous manufacturing of biopharmaceuticals" Oral, ISPE Japan Affiliate Annual Meeting 2019, 30–31 May 2019, Tower Hall Funabori, Tokyo, Japan

Kozue Okamura*, Sara Badr, Hirokazu Sugiyama "Dynamic simulation and process assessment of cell cultivation modes in monoclonal antibody production" Poster, SCEJ 84th Annual Meeting, 13–15 March 2019, Shibaura Institute of Technology, Tokyo, Japan Student Award (Poster)

Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior" Oral, The 33rd European Symposium on Computer-Aided Process Engineering (ESCAPE-33), 18–21 June 2023, Royal Olympic Hotel, Athens, Greece

Yuki Yoshiyama, Sara Badr, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama "Data-driven analysis of charge variants in monoclonal antibody production" Oral, Society of Chemical Engineers, Japan (SCEJ) 53rd Autumn Meeting, 14-16 September 2022, Virtual meeting/Shinshu University, Nagano

Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies", Oral, The 14th International Symposium on Process Systems Engineering (PSE 2021+), 19–23 June 2022, Kyoto University Clock Tower Centennial Hall, Kyoto, Japan/Virtual meeting

Yusuke Ichida, Kensaku Matsunami, Junu Kim, Kozue Okamura, Sara Badr, Hirokazu Sugiyama "Scenario analysis of vaccine supply for COVID-19 using mathematical models of infectious diseases" Poster, Society of Chemical Engineers, Japan (SCEJ) 87th Annual Meeting, 16-18 March 2022, Tsurukabuto Campus, Kobe University, Kobe city, Hyogo/Virtual meeting

Eri Amasawa*, Hiroaki Kuroda, Kozue Okamura, Sara Badr, Hirokazu Sugiyama "Holistic assessment of monoclonal antibody production" Oral, The 17th Meeting of the Institute of Life Cycle Assessment, 2-4 March 2022, Online

Kensaku Matsunami*, Junu Kim, Kozue Okamura, Yusuke Ichida, Shungo Matsueda, Sara Badr, Hirokazu Sugiyama "Mathematical models for infectious diseases considering the impacts of mobility, therapeutic agents, and vaccines" Oral, Society of Chemical Engineers, Japan (SCEJ) 52nd Autumn Meeting, September 2021, Tsushima Campus, Okayama University, Okayama city, Okayama/Virtual meeting

Max Berthet*, Kozue Okamura, Yang Li, Saeko Kawataki, Paul Nadeau "Student-Led Design of Online Tools to Support the Quality of Research Life at the University of Tokyo: A Survey-Based Approach" Oral, 9th European Conference on Education, 15-18 July 2021, Online

Badr Sara*, Okamura Kozue, Takahashi Nozomi, Sugiyama Hirokazu "Assessment of robustness and operational considerations for the design of integrated mAb manufacturing processes" Oral, Society of Chemical Engineers, Japan (SCEJ) 86th Annual Meeting, 20-22 March 2021, Virtual meeting

Sara Badr*, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama "Design of Integrated Monoclonal Antibody Production Processes: Modelling, Data, and Process Challenges" Oral, 2020 AIChE Annual Meeting, 16–20 November 2020, Virtual meeting

Sara Badr*, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production" Oral, The 30th European Symposium on Computer-Aided Process Engineering (ESCAPE-30), 30 August–2 September 2020, Virtual meeting

Max Berthet*, Saeko Kawataki, Kozue Okamura, Mizuki Ishida, Karthik Varada "Understanding and Promoting Gender Diversity Among Senior Faculty at the University of Tokyo: A Student Action Project" Oral, 10th Asian Conference on Cultural Studies, 27–30 May 2020, Online

Sara Badr, Kota Oishi, Kozue Okamura, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling and data-driven parameterization of monoclonal antibody cultivation processes: Shifts in cell metabolic behavior" Elsevier, Computer Aided Chemical Engineering, 52, 985–990 (2023)

Kozue Okamura, Sara Badr, Sei Murakami, Hirokazu Sugiyama "Hybrid modelling of CHO-MK cell cultivation in monoclonal antibody production" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 2137–2142 (2022)

Sara Badr, Kozue Okamura, Nozomi Takahashi, Hirokazu Sugiyama "Techno-economic assessment of upstream and downstream process alternatives for the production of monoclonal antibodies" 14th International Symposium on Process System Engineering, Elsevier, Computer Aided Chemical Engineering, 49, 745–750 (2022)

Sara Badr, Kozue Okamura, Nozomi Takahashi, Vera Ubbenjans, Haruku Shirahata, Hirokazu Sugiyama "Integrated design of biopharmaceutical manufacturing processes: operation modes and process configurations for monoclonal antibody production"Computer Aided Chemical Engineering, 48, 1609–1614 (2020)

Hirokazu Sugiyama, Kozue Okamura, Sara Badr "【Special Feature: Development of Production Technologies for Practical Application of Next-generation Antibody Drugs】Hybrid Modeling of Antibody Drug Manufacturing Process" Seibutsu-kogaku Kaishi, 101, 289–292 (2023)

Kozue Okamura, Sara Badr, Hirokazu Sugiyama "【Pharma PSE Spotlight】A hybrid model of cell cultivation processes in monoclonal antibody production" Pharm Tech Japan, 39, 467–471 (2023)

Kozue Okamura, Sara Badr, Hirokazu Sugiyama "【Pharma PSE Spotlight】Simulation model of cell cultivation process in biopharmaceutical manufacturing and its application to design" Pharm Tech Japan, 38, 1625–1629 (2022)

Kozue Okamura, Kensaku Matsunami, Haruku Shirahata, Hirokazu Sugiyama "Conference report: 2019 American Institute of Chemical Engineers Annual Meeting" Pharm Tech Japan, 36, 149–150 (2020)

Kozue Okamura "人々の健康に貢献する、社会システムを創りたい。"　School of Engineering, The University of Tokyo 【狂ATE the FUTURE】 (2021)

Kozue Okamura "[学生会員の声] 面白さを開拓することの面白さ" 化学工学, 84(1), 43 (2020)